THIOCOUMARINS: FROM THE SYNTHESIS TO THE BIOLOGICAL APPLICATIONS

Thiocoumarins: From the Synthesis to the Biological Applications

Coumarin is a privilege scaffold in medicinal chemistry.Coumarin derivatives are still an emerging class of highly potent pharmaceutical drugs, best known in the field of antimicrobials and anticoagulants.Thiocoumarins are a particular class of coumarins in which CD Player Accessories one or two of the oxygen atoms are replaced by a sulfur.They are

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Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis.

The existence of a hypothalamic gonadotropin-inhibiting system has been elusive.A neuropeptide 4 in 1 Can Cooler named gonadotropin-inhibitory hormone (GnIH, SIKPSAYLPLRF-NH(2)) which directly inhibits gonadotropin synthesis and release from the pituitary was recently identified in quail hypothalamus.Here we identify GnIH homologs in the human hypo

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Excess mortality during the COVID-19 pandemic in low-income and lower middle-income countries: protocol for a systematic review and meta-analysis

Introduction The COVID-19 pandemic has been marked by a massive death toll.However, the overall effect of the pandemic, including potential unintended negative impacts of some control measures, on mortality remains poorly understood in low-income and lower middle-income countries (LLMICs).This review aims to summarise the available literature on ex

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